Togni Reagent: A Hypervalent Iodine Based Electrophilic Trifluoromethylation Reagent
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چکیده
منابع مشابه
Electrophilic fluorination using a hypervalent iodine reagent derived from fluoride.
The air and moisture stable fluoroiodane 8, readily prepared on a 6 g scale by nucleophilic fluorination of the hydroxyiodane 7 with TREAT-HF, has been used as an electrophilic fluorinating reagent for the first time to monofluorinate 1,3-ketoesters and difluorinate 1,3-diketones in good isolated yields.
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An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields. The results provided a versatile approach for the construction of Cvinyl-CF3 bonds without using prefunctionalized substrates.
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ژورنال
عنوان ژورنال: Synlett
سال: 2010
ISSN: 0936-5214,1437-2096
DOI: 10.1055/s-0030-1258548